During the development of long bones in the limbs, chondrocytes lay down a cartilage template. Subsequently, osteoblasts form a bone collar in the perichondrium - the connective tissue that covers the cartilage - and deposit bone matrix throughout the cartilage matrix to form the primary spongiosa, the central part of the bone. On p. 1309, Long et al. propose that Indian hedgehog (Ihh) signalling directly promotes osteogenesis in long bones, probably in conjunction with endogenous factors such as bone morphogenetic proteins. In support of their hypothesis, the researchers show that the removal from perichondrial cells of smoothened (Smo), which encodes a transmembrane protein essential for transducing Ihh signals, prevents the formation of both the bone collar and primary spongiosa. Based on this and other results, the researchers suggest that Ihh acts in vivo on an `osteochondroprogenitor' cell to promote osteoblast differentiation and prevent chondroctye differentiation.
Building bones: role for Indian hedgehog
Building bones: role for Indian hedgehog. Development 15 March 2004; 131 (6): e602. doi:
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The Forest of Biologists
We are excited to announce the launch of The Forest of Biologists, a new biodiversity initiative created with support from the Woodland Trust, aiming to counteract nature loss and safeguard some of the most critically endangered ecosystems for future generations. For every Research Article and Review/Commentary article that is published in JEB (and our sister journals Development, Journal of Cell Science, Disease Models & Mechanisms and Biology Open), a native tree is planted in a forest in the UK.
Propose a new Workshop for 2025
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Pathway to Independence Programme - introducing our first PI Fellows
In December 2022, we announced a new programme aimed at supporting researchers as they transition from postdoc to Principal Investigator. We are delighted to announce that we have now selected our first cohort of PI fellows, meet them here.
Development Journal Meeting 2023
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Call for papers: Metabolic and Nutritional Control of Development and Regeneration
We are welcoming submissions for our next special issue, which will focus on metabolic and nutritional control of development and regeneration. Submission deadline: 15 May 2023.