Planar cell polarity (PCP) studies in the fly have identified several key proteins, such as Strabismus (Stbm), that are required for planar polarity decisions and act by forming asymmetrically localized complexes. In a study of how Stbm functions in this process, Bastock et al. now show, on p. 3007, that Stbm localizes preferentially to the proximal edge of wing cells in the adherens junction zone where other PCP proteins, such as Dishevelled (Dsh) and Prickle (Pk),also localize. Here, Stbm binds directly to Dsh and Pk to recruit them to cell membranes – in its absence, both proteins become mislocalized. In a two-step model, the authors propose that Stbm acts with Frizzled and Flamingo to apicolaterally localize other PCP proteins, including Dsh and Pk. Dsh and Pk then mediate the asymmetric localization of these proteins to the proximal-distal axis.
Strabismus functions in planar polarity
Strabismus functions in planar polarity. Development 1 July 2003; 130 (13): e1302. doi:
Download citation file:
Advertisement
Cited by
Development Journal Meeting 2022: From Stem Cells to Human Development
-JournalMeeting.png?versionId=3737)
Following a virtual meeting in 2020, we are delighted to announce that the fifth iteration of our popular Journal Meeting will be held from 11-14 September 2022 at the historic Wotton House, Surrey. Registration is open now.
Special Issue: The Immune System in Development and Regeneration
(update)-ImmuneSI.png?versionId=3737)
Our latest special issue is now complete. It showcases articles that add to the repertoire of immune cell functions during development, repair and regeneration, and provide insights into the developmental pathways leading to the generation and dispersal of these cells.
Propose a new Workshop
-GSWorkshop.png?versionId=3737)
Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Preprints in Development
(update)-InPreprints.png?versionId=3737)
As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context. You can read the first article here.
FocalPlane Network launched
-FocalPlaneNetworkLaunch.png?versionId=3737)
Like the Node Network, the aim of the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.