Two classes of glial cells are found in the embryonic Drosophila CNS, midline glial cells and lateral glial cells. Midline glial development is triggered by EGF-receptor signalling, whereas lateral glial development is controlled by the gcm gene. Subsequent glial cell differentiation depends partly on the pointed gene. Here we describe a novel component required for all CNS glia development. The tramtrack gene encodes two zinc-finger proteins, one of which, ttkp69, is expressed in all non-neuronal CNS cells. We show that ttkp69 is downstream of gcm and can repress neuronal differentiation. Double mutant analysis and coexpression experiments indicate that glial cell differentiation may depend on a dual process, requiring the activation of glial differentiation by pointed and the concomitant repression of neuronal development by tramtrack.
Glial development in the Drosophila CNS requires concomitant activation of glial and repression of neuronal differentiation genes
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Search Site
K. Giesen, T. Hummel, A. Stollewerk, S. Harrison, A. Travers, C. Klambt; Glial development in the Drosophila CNS requires concomitant activation of glial and repression of neuronal differentiation genes. Development 15 June 1997; 124 (12): 2307–2316. doi: https://doi.org/10.1242/dev.124.12.2307
Download citation file: