We report on the characterization of the first loss-of-function mutation in a Drosophila CREB gene, dCREB-A. In the epidermis, dCREB-A is required for patterning cuticular structures on both dorsal and ventral surfaces since dCREB-A mutant larvae have only lateral structures around the entire circumference of each segment. Based on results from epistasis tests with known dorsal/ventral patterning genes, we propose that dCREB-A encodes a transcription factor that functions near the end of both the DPP- and SPI-signaling cascades to translate the corresponding extracellular signals into changes in gene expression. The lateralizing phenotype of dCREB-A mutants reveals a much broader function for CREB proteins than previously thought.
The Drosophila dCREB-A gene is required for dorsal/ventral patterning of the larval cuticle
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D.J. Andrew, A. Baig, P. Bhanot, S.M. Smolik, K.D. Henderson; The Drosophila dCREB-A gene is required for dorsal/ventral patterning of the larval cuticle. Development 1 January 1997; 124 (1): 181–193. doi: https://doi.org/10.1242/dev.124.1.181
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