We identified four zebrafish mutants with defects in forebrain induction and patterning during embryogenesis. The four mutants define three genes: masterblind (mbl), silberblick (slb), and knollnase (kas). In mbl embryos, the anterior forebrain acquires posterior forebrain characteristics: anterior structures such as the eyes, olfactory placodes and the telencephalon are missing, whereas the epiphysis located in the posterior forebrain is expanded. In slb embryos, the extension of the embryonic axis is initially delayed and eventually followed by a partial fusion of the eyes. Finally, in kas embryos, separation of the telencephalic primordia is incomplete and dorsal midline cells fail to form a differentiated roof plate. Analysis of the mutant phenotypes indicates that we have identified genes essential for the specification of the anterior forebrain (mbl), positioning of the eyes (slb) and differentiation of the roof plate (kas). In an appendix to this study we list mutants showing alterations in the size of the eyes and abnormal differentiation of the lenses.
Become a Node correspondent
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The Node, our community site for developmental and stem cell biologists, is looking to appoint three correspondents who will volunteer to play a key role in developing and writing content over the coming year. Find out more and apply here.
Development presents… a Special Issue on Modelling Development In Vitro
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Our next Development presents… webinar celebrate the Special Issue on Modelling Development In Vitro. Register here to join us online on 11 October at 15:00 BST, or watch the recording on 12 September at 16:00 UK time. You can also watch the recording of our panel discussion from Development’s recent meeting.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context.
Transitions in development: Daniel Ríos Barrera
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Daniel Ríos Barrera’s research group focuses the coordination of cells to form functional tissues during development. We interviewed Daniel to find out more about his career path, his research and his work in promoting science in Mexico.
The Node Network
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The Node Network is a global directory of developmental and stem cell biologists, designed to help you find speakers, referees, panel members and potential collaborators. Find out more about the Node Network.
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