The Eph-related receptor tyrosine kinase gene, Cek-8, is expressed in mesenchyme at the tip of chick limb buds, with high levels of transcripts posteriorly and apically but fading out anteriorly. Expression of Cek-8 in distal mesenchyme is regulated by apical ridge- and FGF-polarising signals and retinoic acid, and is uniform across the anteroposterior axis in talpid3 mutants. These data indicate that Cek-8 expression responds to regulatory signals during limb patterning and suggest that this receptor tyrosine kinase may have a role in coordinating responses to signals in the progress zone of early buds. Later on in limb development, Cek-8 expression is associated with cell condensations that form tendons and their attachments to cartilage rudiments and then in developing feather buds.
Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds
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K. Patel, R. Nittenberg, D. D'Souza, C. Irving, D. Burt, D.G. Wilkinson, C. Tickle; Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds. Development 1 April 1996; 122 (4): 1147–1155. doi: https://doi.org/10.1242/dev.122.4.1147
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