Cell interactions during gastrulation play a key role in the determination of mesodermal cell fates in the sea urchin embryo. An interaction between primary and secondary mesenchyme cells (PMCs and SMCs, respectively), the two principal populations of mesodermal cells, regulates the expression of SMC fates. PMCs are committed early in cleavage to express a skeletogenic phenotype. During gastrulation, they transmit a signal that suppresses the skeletogenic potential of a subpopulation of SMCs and directs these cells into an alternative developmental pathway. This review summarizes present information concerning the cellular basis of the PMC-SMC interaction, as analyzed by cell transplantation and ablation experiments, fluorescent cell labeling methods and the use of cell type-specific molecular markers. The nature and stability of SMC fate switching, the timing of the PMC-SMC interaction and its quantitative characteristics, and the lineage, numbers and normal fate of the population of skeletogenic SMCs are discussed. Evidence is presented indicating that PMCs and SMCs come into direct filopodial contact during the late gastrula stage, when the signal is transmitted. Finally, evolutionary questions raised by these studies are briefly addressed.
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FATE MAPS AND THE MORPHOGENETIC MOVEMENTS OF GASTRULATION| 01 April 1992
Cell interactions and mesodermal cell fates in the sea urchin embryo
Charles A. Ettensohn
Department of Biological Sciences and Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University, 4400 5th Avenue, Pittsburgh, PA 15213, USA
Online Issn: 1477-9129
Print Issn: 0950-1991
Copyright © 1992 by Company of Biologists
Development (1992) 116 (Supplement): 43–51.
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Charles A. Ettensohn; Cell interactions and mesodermal cell fates in the sea urchin embryo. Development 1 April 1992; 116 (Supplement): 43–51. doi: https://doi.org/10.1242/dev.116.Supplement.43
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