It is still unclear whether or not parent-of-origin-dependent differential methylation observed in some transgenes reflects genomic imprinting of endogenous genes. We have characterized a transgene locus showing such methylation imprinting together with the corresponding native chromosome region. We show that only part of the transgene is affected by methylation imprinting and the methylation pattern is established before early prophase I during spermatogenesis. Interestingly, the native genomic region, which is mapped to the proximal chromosome 11, shows no evidence of methylation imprinting but displays heritable, strain-specific type of allelic methylation differences. The results demonstrate that transgenes do not necessarily reflect the methylation status of either the surrounding or corresponding chromosome region. In addition, inherited type of allelic methylation variations previously described in human may be widespread in mammals.
Development Journal Meeting 2022: From Stem Cells to Human Development
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Following a virtual meeting in 2020, we are delighted to announce that the fifth iteration of our popular Journal Meeting will be held from 11-14 September 2022 at the historic Wotton House, Surrey. Registration is open now.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context.
Submit your next Techniques and Resources paper to Development
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Development regularly publishes Techniques and Resources papers. These manuscripts describe a novel technique, a substantial advance of an existing technique, or a new resource that will have a significant impact on developmental biology research. Find out more here.
Transitions in development: Rashmi Priya
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Rashmi Priya’s research group uses the zebrafish heart as a model system to understand the complex morphogenetic events of organogenesis. We interviewed Rashmi to learn about her career path so far, and to discuss the challenges of starting a lab in the middle of a global pandemic.
The Node Network
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The Node Network is a global directory of developmental and stem cell biologists, designed to help you find speakers, referees, panel members and potential collaborators. Find out more about the Node Network.
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