Information necessary for the formation of pole cells, precursors of the germ line, is provided maternally and localized to the posterior pole of the Drosophila egg. The maternal origin and posterior localization of polar granules suggest that they may be associated with pole cell determinants. We have generated an antibody (Mab46F11) against polar granules. In oocytes and early embryos, the Mab46F11 antigen is sharply localized to the posterior embryonic pole. In pole cells, it becomes associated with nuclear bodies within, and nuage around, the nucleus. Immunoreactivity remains associated with cells of the germ line throughout the life cycle of both males and females. This antibody recognizes a 72–74 × 10(3) Mr protein and is useful both as a pole lineage marker and in biochemical studies of polar granules.
Development Presents… Human development: recent progress and ethical challenges
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We will be live-streaming a session from Development’s biennial meeting, From Stem Cells to Human Development, on 12 September at 16:00 UK time. The recording will also be freely available after the event. Find out more.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context.
Submit your next Techniques and Resources paper to Development
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Development regularly publishes Techniques and Resources papers. These manuscripts describe a novel technique, a substantial advance of an existing technique, or a new resource that will have a significant impact on developmental biology research. Find out more here.
Transitions in development: Aman Husbands
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Aman Husbands’ research group focuses on how HD-ZIPIII transcription factors function in different contexts during plant development and evolution. We interviewed Aman to find out more about his career path and the challenges of becoming an independent group leader.
The Node Network
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The Node Network is a global directory of developmental and stem cell biologists, designed to help you find speakers, referees, panel members and potential collaborators. Find out more about the Node Network.
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