Given the growth rate throughout an embryonic rudiment, one can calculate how its parts must shift as it gets bigger, and so plot fate maps showing their future positions. The calculation is done here for the chick wing-bud from stage 18 to stage 25, using published data for mitotic index and cell packing density, and new measurements of size and shape. Two main findings are: (1) the wing-bud in this period elongates almost uniformly along itsproximodistal axis. (2) Each limb segment derives from the tissue generated by one cell division cycle in the ‘progress zone’ at the tip.
Journal Article| 01 April 1975
Fate maps and the pattern of cell division: a calculation for the chick wing-bud
J. H. Lewis
Department of Biology as Applied to Medicine, The Middlesex Hospital Medical School
1Author's address: Department of Biology as Applied to Medicine, The Middlesex Hospital Medical School, London W1P 6DB, U.K.
Received: 24 Jul 1974
Online Issn: 1477-9129
Print Issn: 0950-1991
Copyright © 1975 by Company of Biologists
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J. H. Lewis; Fate maps and the pattern of cell division: a calculation for the chick wing-bud. Development 1 April 1975; 33 (2): 419–434. doi: https://doi.org/10.1242/dev.33.2.419
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