Many animals exhibit innate sexually dimorphic sexual behaviours. Male flies, for example, follow elaborate courtship rituals to secure a female mate. Nervous system sexual dimorphisms probably underlie many sex-specific behaviours, but how are these neuronal dimorphisms generated? On p. 323, David Mellert and colleagues report that one such dimorphism – midline crossing by gustatory (taste) receptor neuron (GRN) axons in male, but not female, Drosophila – is regulated by the sex determination genes fruitless (fru) and doublesex (dsx) and the Roundabout (Robo) axon guidance receptors. fru and dsx are regulated during pre-RNA splicing to produce male- and female-specific isoforms, with female-specific fru mRNA not being translated. The researchers show that, in male flies, male-specific Fru and Dsx promote midline crossing by foreleg GRN axons, whereas in female flies, female-specific Dsx represses midline crossing. They also show that male-specific Fru exerts its effect on midline crossing by directly or indirectly regulating Robo signalling. Together, these results begin to reveal how the neuronal connections that underpin Drosophila sex-specific behaviour are established.
IN THIS ISSUE|
15 January 2010
Nervy sexual dimorphisms
Online Issn: 1477-9129
Print Issn: 0950-1991
© 2010.
2010
Development (2010) 137 (2): e205.
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Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors
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Nervy sexual dimorphisms. Development 15 January 2010; 137 (2): e205. doi:
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