Distinct classes of neural cells differentiate at specific locations within the embryonic vertebrate nervous system. To define the cellular mechanisms that control the identity and pattern of neural cells we have used a combination of functional assays and antigenic markers to examine the differentiation of cells in the developing spinal cord and hindbrain in vivo and in vitro. Our results suggest that a critical step in the dorsoventral patterning of the embryonic CNS is the differentiation of a specialized group of midline neural cells, termed the floor plate, in response to local inductive signals from the underlying notochord. The floor plate and notochord appear to control the pattern of cell types that appear along the dorsoventral axis of the neural tube. The fate of neuroepithelial cells in the ventral neural tube may be defined by cell position with respect to the ventral midline and controlled by polarizing signals that originate from the floor plate and notochord.
CONTROL OF DIRECTED AXON OUTGROWTH|
01 April 1991
Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate
Marysia Placzek,
Marysia Placzek
1Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
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Toshiya Yamada,
Toshiya Yamada
2Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
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Marc Tessier-Lavigne,
Marc Tessier-Lavigne
2Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
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Thomas Jessell,
Thomas Jessell
2Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
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Jane Dodd
Jane Dodd
1Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
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Marysia Placzek
1Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
Toshiya Yamada
2Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
Marc Tessier-Lavigne
2Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
Thomas Jessell
2Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
Jane Dodd
1Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
Online Issn: 1477-9129
Print Issn: 0950-1991
Copyright © 1991 by Company of Biologists
1991
Development (1991) 113 (Supplement_2): 105–122.
Citation
Marysia Placzek, Toshiya Yamada, Marc Tessier-Lavigne, Thomas Jessell, Jane Dodd; Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate. Development 1 April 1991; 113 (Supplement_2): 105–122. doi: https://doi.org/10.1242/dev.113.Supplement_2.105
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