The mouse t-complex is a region of chromosome 17, found in wild mouse populations, which is grossly rearranged when compared to those of normal laboratory strains. So far, two large, independent inversions have been demonstrated. The distal inversion includes the entire Major Histocompatibility Complex (MHC) (Artzt, Shin & Bennett, 1982; Shin et al. 1983; Pla & Condamine, 1984) and the recently discovered proximal inversion (Herrmann et al. 1986) also contains many genes, including the t-complex polypeptide-1 gene (Tcp-1) discussed in this article. Using in situ hybridization, the MHC (Lader et al. 1985) and Tcp-1 (Lyon et al. 1986) genes have been positioned on chromosome 17 and the t-complex would appear to occupy Giemsa bands 17B and 17A3, representing roughly 15 % of the chromosome. Presumably, in addition to those already mapped, many hundreds...
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
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