Left forelimbs of adult newts were repeatedly denervated prior to and following amputation. Limb amputations were performed at 7–, 14–, 21–, 27– and 45-day intervals after the initial denervation. Regeneration was found in the sham-denervated and control animals but did not occur in any of the experimental cases; instead cicatrix formation and dermal wound healing ensued. Soft-tissue dedifferentiation was evident, however. We conclude from these results that forelimb regeneration in the adult newt is completely nerve dependent (for growth).

Copyright © 1983 by Company of Biologists
1983
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