Some features of metabolic activity of homozygous mutants for the Brachyury (T) mutation were studied. The embryos incorporated tritium-labelled thymidine up to about the ‘32-36 somite’ stage. The total amount of protein per embryo increased until the same stage. T/T cells proved viable in vitro over the in utero lethal period. Several cell lines were established from +/+ and T/T embryonic cells.

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