Changes in the extracellular matrix of the cranial cartilages of amphibians

During the differentiation of cranial cartilages the composition of perichordal and perineural extracellular matrix changes: at first only collagen and hyaluronic acid can be detected, later chondroitin-sulphates 4 and 6 appear and their concentrations progressively increase while the concentration of hyaluronic acid is decreasing.

The possible effects of these substances not only on the chondrogenetic cells but also between themselves are discussed.

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