Swimbladder of the crucian carp, Carassius auratus, was found to be better as a vegetali-zing tissue than other tissues, such as guinea-pig bone marrow, when presumptive ectoderm of Trituras gastrulae was used as reacting tissue.

Swimbladder usually induced assemblies of highly organized mesodermal tissues, such as notochord, somites and pronephric tubules, some of which were covered by mesodermal epithelium without an epidermal covering.

A special character of the effect of swimbladder was the rather frequent induction of solid balls of undifferentiated cells, which were identified as mesodermal or mesodermal and probably endodermal. These findings show that swimbladder has a strong and fast spreading vegetalizing effect on the responding presumptive ectoderm.

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