ABSTRACT
Induction of skin allograft tolerance in chimaeras of urodele amphibian, Pleurodeles waltlii Michah
Allogenic chimaeras were produced in Pleurodeles waltlii (Amphibian, Urodele) by associating the anterior and the posterior parts of two different embryos. A reciprocal exchange between two homologue embryos gave rise to reciprocal allogenic chimaeras.
Skin grafts performed in the adult stage between two reciprocal chimaeras are always tolerated. On the other hand, when two skin grafts coming from the anterior and the posterior part of one chimaera are grafted on a common host, one of them may be tolerated and the other rejected : each part of a chimaera keeps its own antigenicity.
In allogenic chimaeras, the average natural tolerance for skin allografts is 30 % higher than in sibling controls.
Copyright © 1974 by Company of Biologists
1974
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