ABSTRACT
The effect of treatment of chick embryos during the first day of incubation with a number of sugars is described. To some embryos solid sugars were applied in opened eggs; for others the substances were injected in solution. By both methods, all sugars tested were found to be teratogenic, but no apparent general differences between mono-, di-, and trisaccharides were found. Nor were there any correlations between those which can be metabolised at these stages and their teratogenicity.
The range of defects produced is similar to those found when embryos of this age are treated with other substances. In embryos treated with [14C]sucrose, some of the label is retained within the tissues in a bound, insoluble form. Possible implications of this finding are suggested.