1. Evidence is presented demonstrating that although a short burst of oxygen uptake follows transfer of Rana pipiens embryos from a nitrogen to an oxygen atmosphere, a similar burst follows transfer from air to oxygen. Since the material being oxidized exists in the reduced state in gastrulae raised in air, it cannot constitute a major source of anaerobic oxidations in gastrulae. Data and considerations suggesting that the amphibian embryo is normally partially anaerobic in the usual temperature range employed in physiological experiments are presented.

  2. A detailed description of the respiratory and lactate level changes of embryos transferred to an oxygen atmosphere after anaerobiosis is given and the significance of the findings is discussed.

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