It has been shown that congenital malformations can be produced in rats by injection into the pregnant female of rat kidney antiserum (Brent, Averich & Drapiewski, 1961 ; Brent, 1966a, b) or heterologous placental antiserum (Brent, 1966a, b, 1967). The teratogenic factor has been localized in the gammaglobulin fraction of the serum (Brent, 1966b).

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