ABSTRACT
The activities of aminolaevulinate synthetase, aminolaevulinate dehydratase and haem synthetase have been examined in short-term cultures of embryonic mouse liver.
Although synthesis of haemoglobin was induced by erythropoietin in these cultures no increase in activity was detected in any of the three enzymes over 24 h in culture. In each case, however, enzyme activity was higher when erythropoietin was present than in its absence.
The significance of these findings is discussed in relation to control of haemoglobin synthesis and it is concluded that enzyme activity is not rate limiting during induction of haemoglobin synthesis in vitro.
Copyright © 1972 by Company of Biologists
1972
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