In previous papers it has been shown that living nuclei of animal hemisphere cells of frog blastulae and early gastrulae can be transferred into enucleated eggs (Briggs & King, 1952,1953a). Approximately 20 per cent, to 40 per cent, of the recipient eggs cleave normally, and the majority of these develop into complete embryos, demonstrating that the transplanted nuclei are undifferentiated (i.e. still capable of participating in all types of differentiation). This result is more or less expected since the nuclei in question come from undifferentiated parts of the blastula and early gastrula.

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