ABSTRACT
In the course of differentiation, in the overwhelming majority of cases, the cell genotype remains unchanged. However, tissue differences are inherited during cell reproduction (histiotypic growth). This means that the effects of determining influences are as a rule totally or almost totally irreversible, and hence only de-differentiation and not de-determination can take place. There is no return to a state from which different ways of development may be chosen.
Copyright © 1968 by Company of Biologists
1968
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