Information concerning physical and chemical properties of serum albumin during the development of the chick has been collected by different techniques, e.g. paper, gel and continuous flow electrophoresis, ultracentrifugation and immunochemical methods. However, the results of the various authors are not always in full agreement. The main questions deal with the precise stage of development when serum albumin can first be detected in the circulating blood, and with the heterogeneity of the molecular types in the group of serum albumins. Other aspects of the problem concern the possibility of different origins of serum albumin at various stages and the metabolism of this protein which probably has peculiar features at each intra- and extra-ovular developmental period (Iványi, Hraba & Cerny, 1964).

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