ABSTRACT
The effect of 2,4-dinitrophenol, an uncoupler of oxidative phosphorylation, has been studied on the chick embryo developing in vitro.
2,4-dinitrophenol in concentrations ranging between 10−4 M and 2 x 10−3 M causes a syndrome of abnormalities, the main features of which are degeneration and sometimes complete absence of neural tissue accompanied by reduction in number of and inhibition of the somites. Heart, notochord and blood islands are unaffected.
A comparison is drawn between the effects of 2,4-dinitrophenol and other substances which affect the development of neural tissue and somites in explanted chick embryos.
Copyright © 1967 by Company of Biologistss
1967
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