ABSTRACT
Chloroacetophenone (CAP), a specific inhibitor of SH groups, applied at 5 × 10−4 M for 15 min at the definitive primitive streak stage of chick embryos causes abnormalities, predominantly in the nervous system.
The effects of CAP can be reversed by a subsequent treatment with thiomalic acid (5 × 10−4) or glutathione (1 × 10−5 M).
Equimolar concentration of serine (4 × 10−4), which is structurally similar to cysteine except that SH of cysteine is replaced by OH in serine, fails to reverse the effects of CAP.
The results of the present work suggest that the reversal of the CAP effects is brought about by SH groups.
Copyright © 1967 by Company of Biologistss
1967
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