ABSTRACT
The influence of testosterone propionate upon the central sexual maturation of the male rat has been investigated.
Male rats castrated on the day of birth and injected with testosterone propionate at 5, 10 or 20 days of age had immature ovarian tissue transplanted to the anterior chamber of one eye when 3 months old.
Ovarian grafts in castrate males injected with testosterone at 5 or 10 days of age did not show cyclical activity. Grafts in non-injected castrates or hosts injected with testosterone at 20 days of age showed cyclical activity.
The site of action of testosterone is discussed, and it is suggested that it may have an inductive influence upon the sexual maturation of the rat brain.
Copyright © 1967 by Company of Biologists
1967
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