ABSTRACT
Stem cell-based embryo models (SCBEMs) are structures generated from three-dimensional (3D) culture of pluripotent stem cells and their derivatives, utilizing mechanical and/or chemical cues to facilitate lineage differentiation, self-organization and morphogenesis. These models partially mimic early embryos, which would otherwise be difficult to access. SCBEMs have been established in mice, livestock, nonhuman primates and humans. Here, we focus on recently developed human models, with an emphasis on the peri-implantation stage and the aspects of human development these SCBEMs recapitulate.
Footnotes
Funding
J.W. is a New York Stem Cell Foundation – Robertson investigator and a Virginia Murchison Linthicum Scholar in medical research. Research in the Wu laboratory is supported by the National Institutes of Health (UM1HG011996, R01HD103627 and R01GM138565), the New York Stem Cell Foundation, the American Society For Reproductive Medicine and The Welch Foundation (I-2088). Deposited in PMC for release after 12 months.
High-resolution poster
A high-resolution version of the poster is available for downloading at https://journals.biologists.com/dev/article-lookup/doi/10.1242/dev.204543#supplementary-data
