ABSTRACT
Tubes are crucial for the function of many organs in animals given their fundamental roles in transporting and exchanging substances to maintain homeostasis within an organism. Therefore, the development and maintenance of these tube-like structures within organs is a vital process. Tubes can form in diverse ways, and advances in our understanding of the molecular and cellular mechanisms underpinning these different modes of tubulogenesis have significant impacts in many biological contexts, including development and disease. This Review discusses recent progress in understanding developmental mechanisms underlying tube formation.
Footnotes
Funding
This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK115655 to R.K.M.). B.L.W. is supported through a training fellowship from the Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston T32 Program (TL1TR003169 and T32TR004905 to Drs Jeffrey Frost and Joya Chandra) and the President's Research Excellence Award from The University of Texas MD Anderson Cancer Center University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences. L.Y. is supported by a training fellowship from the National Institute of General Medical Sciences (T32GM135118 to Dr Holger K. Eltzschig), and a 2023-2024 Department of Pediatrics Pilot Research Grant Award (to L.Y.). Deposited in PMC for release after 12 months.
