ABSTRACT
In eukaryotic cells, the genetic material is organized into chromatin, which consists mainly of DNA, histones and chromatin-associated proteins. An important regulator of chromatin structure and function are histone post-translational modifications, which can shape gene expression patterns and control the epigenetic landscape. Here, we summarize the role of some key histone modifications in animal development, with a focus on the two best-studied types of histone modifications: lysine methylation and acylations, specifically, acetylation.
Footnotes
Funding
This work was supported by the Deutsche Forschungsgemeinschaft (German Research Foundation) through S.F.B. 1064 (Project-ID 213249687) and S.F.B. 1309 (Project-ID 325871075) as well as the Helmholtz-Gemeinschaft.
High-resolution poster
A high-resolution version of the poster is available for downloading at https://journals.biologists.com/dev/article-lookup/doi/10.1242/dev.204384#supplementarydata
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