ABSTRACT
The development of the esophagus in the crooked neck dwarf was studied between
and 12 days of incubation (stages 26 –38).Esophageal histogenesis in the crooked neck dwarf resembles normal development up to stage 33.
Vésiculation alone does not cause the reopening of the esophagus, which depends on the participation of epithelial degeneration to complete the process.
Studies of epithelial degeneration in the mutant esophagus emphasize its caudo-cephalic gradient in the reopening process.
The appearance of clefts in the intervesicular epithelium suggests that tension plays a role in the reopening process.
The occluded segments and persisting epithelial strands of the 18-day mutant embryonic esophagus result from critical developmental failures at 8 days of incubation (stage 34).
The crooked neck dwarf mutant has a histogenetic marker in the form of ‘degenerate mesenchyme cells’ as early as stage 30.
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