ABSTRACT
Collective cell migration is the coordinated movement of a physically connected group of cells and is a prominent driver of development and metastasis. Interactions between cells within migrating collectives, and between migrating cells and other cells in the environment, play key roles in stimulating motility, steering and sometimes promoting cell survival. Similarly, diverse heterotypic interactions and collective behaviors likely contribute to tumor metastasis. Here, we describe a sampling of cells that migrate collectively in vivo, including well-established and newer examples. We focus on the under-appreciated property that many – perhaps most – collectively migrating cells move as cooperating groups of distinct cell types.
Footnotes
Funding
J.P.C. is supported by an American Cancer Society Postdoctoral Fellowship (PF-17-024-01-CSM). This work was supported by a National Institutes of Health grant (R01 GM46425 to D.J.M.). Deposited in PMC for release after 12 months.
