One of the most prominent features of vertebrate evolution is the formation of the skeletal system, which consists of cartilage and/or bone. The skeletal system is essential to all vertebrate species; it provides the body with shape and form, supports it, protects the internal organs, allows body movement, houses blood stem cells, stores minerals and even acts as an endocrine organ to regulate general metabolism and homeostasis. However, for some time, the biology of the skeletal system escaped most people's attention because it was viewed as not being quite so ‘alive’ as other tissues and because the high mineral content of the skeleton led people to believe that it consists largely of ‘pieces of rock’. Thanks to the recent application of genetic, molecular and cellular tools to the study of the skeletal system, the past two decades have seen a tremendous explosion of seminal discoveries about this biological system. Now...
Fleshing out the skeletal system Available to Purchase
Yingzi Yang; Fleshing out the skeletal system. Development 15 December 2009; 136 (24): 4069–4070. doi: https://doi.org/10.1242/dev.040576
Download citation file:
Sign in
Client Account
Sign in via your institution
Sign in via ShibbolethAdvertisement
Cited by
The Company of Biologists Workshops

For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues

Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows

We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
A case for broadening our view of mechanism in developmental biology

In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
the Node: Have your say

Our community site, the Node, is conducting a user survey about the content and the design of the site. Help us shape the Node's future and thank you for being a part of the Node over the last 15 years.