The mid/hindbrain is an excellent model for studying 3D tissue patterning,but although its anteroposterior (AP) patterning is well characterised,dorsoventral (DV) patterning is not. Now, Blaess et al. (p. 1799) have used conditional mutagenesis to investigate how sonic hedgehog (Shh) directs DV patterning. Shh has two signalling modes involving the Gli transcription factors: in Gli2A-mediated Shh signalling, Shh converts Gli2 into a transcriptional activator; and in Gli3R-mediated Shh signalling, Shh opposes the processing of Gli3 into a repressor. The authors conditionally removed all Shh signalling (by mutating the receptor Smo) or just Gli2A-mediated Shh signalling (by mutating Gli2) at E9.0 or at E11.5 in the mouse mid/hindbrain. Gli2A-mediated signalling was needed early on for ventral patterning and for the dorsal restriction of Gli3 transcription. Gli3R-mediated signalling was important throughout for the development of dorsal structures and before E11 for regulating growth by inhibiting apoptosis. Gli3R-mediated Shh signalling also...
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows
We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
the Node: Have your say
Our community site, the Node, is conducting a user survey about the content and the design of the site. Help us shape the Node's future and thank you for being a part of the Node over the last 15 years.
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