Improving our understanding of the mechanisms that govern cell motility and invasion is crucial for understanding development and how these processes go awry in metastasis. Border cell migration during Drosophila oogenesis is a well-studied model of invasive and directed migration, which has now been analysed by Abdelilah-Seyfried et al. in flies mutant for bazooka andDaPKC (components of an epithelial polarity- and adhesion-regulating complex) and for the tumour suppressor genes, dlg1 and lgl. Their findings on p. 1927 show that the aberrant invasion of germ cells by dlg1- follicle epithelial cells surprisingly requires wild-type Bazooka function, possibly because Bazooka stabilizes adhesion between the invading somatic cells and their germ-cell substratum. By contrast, Bazooka function is dispensable for border cell invasion and motility, perhaps because it mediates cell adhesion within the migrating border cell cluster. These findings reveal distinct functions for Bazooka during different types of epithelial cell invasion....
Interviews with Biologists @ 100 conference speakers
Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
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