Improving our understanding of the mechanisms that govern cell motility and invasion is crucial for understanding development and how these processes go awry in metastasis. Border cell migration during Drosophila oogenesis is a well-studied model of invasive and directed migration, which has now been analysed by Abdelilah-Seyfried et al. in flies mutant for bazooka andDaPKC (components of an epithelial polarity- and adhesion-regulating complex) and for the tumour suppressor genes, dlg1 and lgl. Their findings on p. 1927 show that the aberrant invasion of germ cells by dlg1- follicle epithelial cells surprisingly requires wild-type Bazooka function, possibly because Bazooka stabilizes adhesion between the invading somatic cells and their germ-cell substratum. By contrast, Bazooka function is dispensable for border cell invasion and motility, perhaps because it mediates cell adhesion within the migrating border cell cluster. These findings reveal distinct functions for Bazooka during different types of epithelial cell invasion....
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows
We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
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