1. The effect of sodium azide on the processes of cleavage in Planorbis exustus has been studied.

  2. The phase of cleavage division at which treatment is begun and the delay caused in subsequent divisions have a definite relationship to each other. The delay caused by azide, after it becomes apparent, does not progressively increase but is maintained.

  3. The results are discussed from the point of view of the energy mechanism involved. A reservoir system, probably of phosphorylated compounds, seems to operate. When carbohydrate metabolism is selectively inhibited at some point in the Embden-Meyerhof pathway, the embryos seem to be capable of metabolizing fats for the purposes of deriving energy for the cleavage processes.

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