ABSTRACT
The abnormalities of the inner ear in dreher mice may be viewed as the consequences of an incomplete or weak differentiation of the otic vesicle.
As it is known from experimental work on other vertebrates that this differentiation depends on the inductive influence of the neural tube, it was thought that the neural tube might be abnormal in these animals.
It was found that not only is the neural tube abnormal, but its abnormalities are seen at least one day before those of the inner ear.
The relevance of these findings to mutants with defects of the eyes is discussed.
Copyright © 1964 by Company of Biologists
1964
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