ABSTRACT
Neural retina from chick embryos 6 to 14 day incubation was cultured either as intact fragments or as populations of dispersed cells following enzymatic dissociation into a suspension of single cells. Within 10 to 24 hr., 95 to 100 per cent, of the cells cultured as populations of dispersed cells transformed into pigmented cells reminiscent of, but not identical to, those of pigmented retina. This transformation did not occur in intact fragments of neural retina similarly cultured.
The nature of the mechanism by which the transformation occurs has been experimentally investigated. The results indicate that some unstable inhibitor of tyrosinase may be responsible for the unorthodox differentiation of these cells.
Copyright © 1964 by Company of Biologists
1964
You do not currently have access to this content.