ABSTRACT
Amongst the numerous derivatives of nitrogen mustard that have been tested for their anti-tumour activity on Walker carcinoma by Danielli and his collaborators (1961), (Cl—CH2—CH2)2:N—C6H4—O—CO—NH—C6H4—COOH, i.e., p-(7V7V-Di-2-chloroethyloamino)-phenyl - N-(p-carboxyphenyl) - carbamate (later referred to as I.C. 140), has been found to be particularly promising. To check its cytotoxic activity for embryos, and to find out, if possible, whether I.C. 140 has any specific selectivity for particular embryonic tissues, chick and mouse embryos were treated during the early stages of development.
Copyright © 1963 by Company of Biologists
1963
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