ABSTRACT
A simple method for applying heat shock directly to the uterus of pregnant rats is described.
In an experimental series a temperature of 40–41 °C. was maintained for 40 min. A number of malformed foetuses were observed, and the resorption rate was high.
In a control series animals were operated upon in the same manner as the experimental ones, but the temperature was kept at 37–38°C. No malformations were found.
Deformities of the head and extremities were produced by the heat shock.
These malformations are compared with those produced by other teratogens, and the differences are discussed.
Copyright © 1963 by Company of Biologists
1963
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