1. Tyrode salt solution when injected into the blood-stream of young chicken embryos will cause the appearance of malformed embryos in the 1st and 2nd filial generation derived from the recipient birds. The frequency of malformed embryos appears to be correlated with the amount of substance injected.

    The rate of the appearance of malformations at least in the 1st filial generation is increased when DNA dissolved in Tyrode is injected into the recipient embryo. It also appears that the percentage of malformed embryos rises if the amount of DNA is increased by repeated intermittent injections.

    The recipient embryos themselves do not develop malformations unless relatively high doses are given to them by repeated injections.

  2. Tyrode solution has a definite injurious effect on the gonad of recipient female birds and on the gonads of their Fx progeny, which is expressed in a number of ways. The same effect has been observed in the recipients of both the F1 and F2 from DNA-treated birds.

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