1. The pineal bodies of 4 and of 9-12 days old chick embryos were cultivated by Fell’s watchglass technique.

  2. The rate of differentiation was almost normal, but the growth-rate was retarded in vitro.

  3. The pineal body of 4 and of 9-12 days old embryonic fowl therefore possesses a capacity for self-differentiation which is independent of either bloodsupply or of endocrine stimulation.

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