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Heart Disease

Despite significant progress, cardiac disease that results in heart failure remains a significant clinical and scientific challenge. This collection, launching with our upcoming special issue Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy , guest edited by Jeroen Bakkers, Milena Bellin and Ravi Karra, includes research and review-type articles on the dysregulation of pathways, disease progression, and approaches to treat and modify the course of heart failure.

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SPECIAL ARTICLE

Beyond genomic studies of congenital heart defects through systematic modelling and phenotyping

Deborah J. Henderson; Ahlam Alqahtani; Bill Chaudhry; Andrew Cook; Lorraine Eley; Lucile Houyel; Marina Hughes; Bernard Keavney; José Luis de la Pompa; John Sled; Nadine Spielmann; Lydia Teboul; Stephane Zaffran; Pleasantine Mill; Karen J. Liu

22 November 2024

https://doi.org/10.1242/dmm.050913

RESOURCES & METHODS

Functional cardiac consequences of β-adrenergic stress-induced injury in a model of Duchenne muscular dystrophy

Conner C. Earl; Areli J. Javier; Alyssa M. Richards; Larry W. Markham; Craig J. Goergen; Steven S. Welc

09 October 2024

https://doi.org/10.1242/dmm.050852

RESEARCH ARTICLE

Deficient GATA6–CXCR7 signaling leads to bicuspid aortic valve

Rebeca Piñeiro-Sabarís; Donal MacGrogan; José Luis de la Pompa

10 September 2024

https://doi.org/10.1242/dmm.050934

RESEARCH ARTICLE

Reduced connexin-43 expression, slow conduction and repolarisation dispersion in a model of hypertrophic cardiomyopathy

Seakcheng Lim; Melissa M. Mangala; Mira Holliday; Henrietta Cserne Szappanos; Samantha Barratt-Ross; Serena Li; Jordan Thorpe; Whitney Liang; Ginell N. Ranpura; Jamie I. Vandenberg; Christopher Semsarian; Adam P. Hill; Livia C. Hool

27 August 2024

https://doi.org/10.1242/dmm.050407

RESEARCH ARTICLE

The glucocorticoid receptor acts locally to protect dystrophic muscle and heart during disease

Trinitee Oliver; Nhu Y. Nguyen; Christopher B. Tully; Nikki M. McCormack; Christina M. Sun; Alyson A. Fiorillo; Christopher R. Heier

21 May 2024

https://doi.org/10.1242/dmm.050397

RESEARCH ARTICLE

In silico study of the mechanisms of hypoxia and contractile dysfunction during ischemia and reperfusion of hiPSC cardiomyocytes

Mohamadamin Forouzandehmehr; Michelangelo Paci; Jari Hyttinen; Jussi T. Koivumäki

26 April 2024

https://doi.org/10.1242/dmm.050365

RESEARCH ARTICLE

eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling

Lorraine Eley; Rachel V. Richardson; Ahlam Alqahtani; Bill Chaudhry; Deborah J. Henderson

22 January 2024

https://doi.org/10.1242/dmm.050265

REVIEW

Nuclear mechanosensing of the aortic endothelium in health and disease

Aarren J. Mannion; Lars Holmgren

01 November 2023

https://doi.org/10.1242/dmm.050361

RESEARCH ARTICLE

Comparative multi-omic analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency

Nicole M. Sayles; Jill S. Napierala; Josef Anrather; Nadège Diedhiou; Jixue Li; Marek Napierala; Hélène Puccio; Giovanni Manfredi

09 October 2023

https://doi.org/10.1242/dmm.050114

RESEARCH ARTICLE

Modeling a variant of unknown significance in the Drosophila ortholog of the human cardiogenic gene NKX2.5

TyAnna L. Lovato; Brenna Blotz; Cayleen Bileckyj; Christopher A. Johnston; Richard M. Cripps

29 September 2023

https://doi.org/10.1242/dmm.050059

RESEARCH ARTICLE

CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease

Lino Doering; Alex Cornean; Thomas Thumberger; Joergen Benjaminsen; Beate Wittbrodt; Tanja Kellner; Omar T. Hammouda; Matthias Gorenflo; Joachim Wittbrodt; Jakob Gierten

16 August 2023

https://doi.org/10.1242/dmm.049811

RESEARCH ARTICLE

Multiplatform modeling of atrial fibrillation identifies phospholamban as a central regulator of cardiac rhythm

Anaïs Kervadec; James Kezos; Haibo Ni; Michael Yu; James Marchant; Sean Spiering; Suraj Kannan; Chulan Kwon; Peter Andersen; Rolf Bodmer; Eleonora Grandi; Karen Ocorr; Alexandre R. Colas

17 July 2023

https://doi.org/10.1242/dmm.049962

RESEARCH ARTICLE

Immature human engineered heart tissues engraft in a guinea pig chronic injury model

Constantin von Bibra; Aya Shibamiya; Andrea Bähr; Birgit Geertz; Maria Köhne; Tim Stuedemann; Jutta Starbatty; Verena Horneffer-van der Sluis; Ulrich C. Klostermeier; Nadja Hornaschewitz; Xinghai Li; Eckhard Wolf; Nikolai Klymiuk; Markus Krane; Christian Kupatt; Bernhard Hiebl; Thomas Eschenhagen; Florian Weinberger

05 June 2023

https://doi.org/10.1242/dmm.049834

EDITORIAL

From mechanisms of heart failure to clinical heart success

Jeroen Bakkers; Milena Bellin; Julija Hmeljak; Ravi Karra

05 June 2023

https://doi.org/10.1242/dmm.050282

RESEARCH ARTICLE

Deficiency in hereditary hemorrhagic telangiectasia-associated Endoglin elicits hypoxia-driven heart failure in zebrafish

Etienne Lelièvre; Charlotte Bureau; Yann Bordat; Maxence Frétaud; Christelle Langevin; Chris Jopling; Karima Kissa

02 June 2023

https://doi.org/10.1242/dmm.049488