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Drug Discovery
Model systems are central to the discovery and development of new and better treatments for human disease. This collection, first launched in 2015 with a special issue titled From Bench to Patient: Model Systems in Drug Discovery, guest edited by Matthew Breyer and Thomas Look, highlights the contribution of model systems to drug discovery and optimisation across multiple disease areas. It features Reviews and Research articles on the use of model systems to test or develop new therapies.
SPECIAL ARTICLE
Muthukumar Karuppasamy; Katherine G. English; Clarissa A. Henry; M. Chiara Manzini; John M. Parant; Melissa A. Wright; Avnika A. Ruparelia; Peter D. Currie; Vandana A. Gupta; James J. Dowling; Lisa Maves; Matthew S. Alexander
18 January 2024
RESEARCH ARTICLE
Julie Bejoy; Justin M. Farry; Eddie S. Qian; Curtis H. Dearing; Lorraine B. Ware; Julie A. Bastarache; Lauren E. Woodard
01 December 2023
RESEARCH ARTICLE
Sijia Fan; Jinlong Jiang; Huan Zhang; Cuihong Wang; Shang Kong; Tingting Zhao; Ling Meng; Yang Liu; Jingjing Qin; Xiuqin Rong; Zhenting He; Qinke He; Ke He; Ketong Chen; Ling Lei; Xinyu Hai; Hong Nie; Chunguang Ren
13 October 2023
RESEARCH ARTICLE
Vemurafenib improves muscle histopathology in a mouse model of LAMA2 -related congenital muscular dystrophy
Open Access
Ariany Oliveira-Santos; Marisela Dagda; Jennifer Wittmann; Robert Smalley; Dean J. Burkin
10 May 2023
RESOURCE ARTICLE
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology
Open Access
Patricia K. Dranchak; Erin Oliphant; Bryan Queme; Laurence Lamy; Yuhong Wang; Ruili Huang; Menghang Xia; Dingyin Tao; James Inglese
20 March 2023
RESEARCH ARTICLE | REVIEW COMMONS TRANSFER
Sabrina Yahiya; Charlie N. Saunders; Sarah Hassan; Ursula Straschil; Oliver J. Fischer; Ainoa Rueda-Zubiaurre; Silvia Haase; Gema Vizcay-Barrena; Mufuliat Toyin Famodimu; Sarah Jordan; Michael J. Delves; Edward W. Tate; Anna Barnard; Matthew J. Fuchter; Jake Baum
30 January 2023
RESOURCE ARTICLE
Jennifer K. Sargent; Mark A. Warner; Benjamin E. Low; William H. Schott; Todd Hoffert; David Coleman; Xing Yi Woo; Todd Sheridan; Sonia Erattupuzha; Philipp P. Henrich; Vivek M. Philip; Jeffrey H. Chuang; Michael V. Wiles; Muneer G. Hasham
29 August 2022
RESOURCE ARTICLE
Madelyn M. Jackstadt; Casey A. Chamberlain; Steven R. Doonan; Leah P. Shriver; Gary J. Patti
16 August 2022
REVIEW
The benefits, limitations and opportunities of preclinical models for neonatal drug development
Open Access
Sarah Campion; Amy Inselman; Belinda Hayes; Costanza Casiraghi; David Joseph; Fabrizio Facchinetti; Fabrizio Salomone; Georg Schmitt; Julia Hui; Karen Davis-Bruno; Karen Van Malderen; LaRonda Morford; Luc De Schaepdrijver; Lutz Wiesner; Stephanie Kourula; Suna Seo; Susan Laffan; Vijay Urmaliya; Connie Chen
25 April 2022
RESOURCE ARTICLE
Agustin Resendiz-Sharpe; Roberta Peres da Silva; Elena Geib; Lore Vanderbeke; Laura Seldeslachts; Charlien Hupko; Matthias Brock; Katrien Lagrou; Greetje Vande Velde
30 March 2022
RESEARCH ARTICLE
Nazia M. Alam; Robert M. Douglas; Glen T. Prusky
21 February 2022
RESEARCH ARTICLE
Two cell line models to study multiorganic metastasis and immunotherapy in lung squamous cell carcinoma
Open Access
Karmele Valencia; Cristina Sainz; Cristina Bértolo; Gabriel de Biurrun; Jackeline Agorreta; Arantza Azpilikueta; Marta Larrayoz; Graziella Bosco; Carolina Zandueta; Miriam Redrado; Esther Redín; Francisco Exposito; Diego Serrano; Mirari Echepare; Daniel Ajona; Ignacio Melero; Ruben Pio; Roman Thomas; Alfonso Calvo; Luis M. Montuenga
31 January 2022
RESEARCH ARTICLE
Roger S. Smith; Igor Odintsov; Zebing Liu; Allan Jo-Weng Lui; Takuo Hayashi; Morana Vojnic; Yoshiyuki Suehara; Lukas Delasos; Marissa S. Mattar; Julija Hmeljak; Hillary A. Ramirez; Melissa Shaw; Gabrielle Bui; Alifiani B. Hartono; Eric Gladstone; Siddharth Kunte; Heather Magnan; Inna Khodos; Elisa De Stanchina; Michael P. La Quaglia; Jinjuan Yao; Marick Laé; Sean B. Lee; Lee Spraggon; Christine A. Pratilas; Marc Ladanyi; Romel Somwar
27 January 2022
RESEARCH ARTICLE
Eva Habjan; Vien Q. T. Ho; James Gallant; Gunny van Stempvoort; Kin Ki Jim; Coen Kuijl; Daan P. Geerke; Wilbert Bitter; Alexander Speer
23 December 2021
RESEARCH ARTICLE
Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection
Open Access
Kamlesh Bhatt; Madhuri Bhagavathula; Sheetal Verma; Graham S. Timmins; Vojo P. Deretic; Jerrold J. Ellner; Padmini Salgame
26 October 2021
PERSPECTIVE
James F. Amatruda
22 February 2021
RESEARCH ARTICLE
Henrika Jodeleit; Paula Winkelmann; Janina Caesar; Sebastian Sterz; Lesca M. Holdt; Florian Beigel; Johannes Stallhofer; Simone Breiteneicher; Eckart Bartnik; Thomas Leeuw; Matthias Siebeck; Roswitha Gropp
21 January 2021
RESEARCH ARTICLE
Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2 −/− animals
Open Access
Lozan Sheriff; Reenam S. Khan; Raquel Saborano; Richard Wilkin; Nguyet-Thin Luu; Ulrich L. Gunther; Stefan G. Hubscher; Philip N. Newsome; Patricia F. Lalor
29 December 2020
RESEARCH ARTICLE
Katie Lloyd; Stamatia Papoutsopoulou; Emily Smith; Philip Stegmaier; Francois Bergey; Lorna Morris; Madeleine Kittner; Hazel England; Dave Spiller; Mike H. R. White; Carrie A. Duckworth; Barry J. Campbell; Vladimir Poroikov; Vitor A. P. Martins dos Santos; Alexander Kel; Werner Muller; D. Mark Pritchard; Chris Probert; Michael D. Burkitt; The SysmedIBD Consortium
27 November 2020
REVIEW
Alec M. DeSimone; Justin Cohen; Monkol Lek; Angela Lek
28 October 2020
