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Cancer Metabolism

The complex metabolic cross-talk between cancer cells and their environment highlights the importance of advanced in vitro and in vivo models for studying cancer metabolism, providing incentive for the continued development of improved models to facilitate translation. This collection features Research articles, Reviews and interviews, including specially commissioned content from our 2018 special issue Cancer Metabolism: Models, Mechanisms and Targets, which was guest edited by Almut Schulze and Mariia Yuneva.

Other subject collections

REVIEW

Metabolic ripple effects – deciphering how lipid metabolism in cancer interfaces with the tumor microenvironment

Patrick B. Jonker; Alexander Muir

16 September 2024

https://doi.org/10.1242/dmm.050814

REVIEW

Understanding the interplay between dNTP metabolism and genome stability in cancer

Miriam Yagüe-Capilla; Sean G. Rudd

29 August 2024

https://doi.org/10.1242/dmm.050775

REVIEW

Membrane transporters in cell physiology, cancer metabolism and drug response

Sara Alam; Emily Doherty; Paula Ortega-Prieto; Julia Arizanova; Louise Fets

01 December 2023

https://doi.org/10.1242/dmm.050404

RESEARCH ARTICLE

Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation

Guia Cerretelli; Ying Zhou; Mike F. Müller; David J. Adams; Mark J. Arends

31 July 2023

https://doi.org/10.1242/dmm.050240

REVIEW

Cancer cachexia: lessons from Drosophila

Ying Liu; Pedro Saavedra; Norbert Perrimon

23 March 2022

https://doi.org/10.1242/dmm.049298

RESOURCE ARTICLE

The MEMIC is an ex vivo system to model the complexity of the tumor microenvironment

Libuše Janská; Libi Anandi; Nell C. Kirchberger; Zoran S. Marinkovic; Logan T. Schachtner; Gizem Guzelsoy; Carlos Carmona-Fontaine

18 August 2021

https://doi.org/10.1242/dmm.048942

REVIEW

Metabolic reprogramming in cancer: mechanistic insights from Drosophila

Kenneth Kin Lam Wong; Esther M. Verheyen

09 July 2021

https://doi.org/10.1242/dmm.048934

RESEARCH ARTICLE

Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney

Garrett Brinkley; Hyeyoung Nam; Eunhee Shim; Richard Kirkman; Anirban Kundu; Suman Karki; Yasaman Heidarian; Jason M. Tennessen; Juan Liu; Jason W. Locasale; Tao Guo; Shi Wei; Jennifer Gordetsky; Teresa L. Johnson-Pais; Devin Absher; Dinesh Rakheja; Anil K. Challa; Sunil Sudarshan

27 November 2020

https://doi.org/10.1242/dmm.045898

RESEARCH ARTICLE

The SDHB Arg230His mutation causing familial paraganglioma alters glycolysis in a new Caenorhabditis elegans model

Éva Saskői; Zoltán Hujber; Gábor Nyírő; István Likó; Barbara Mátyási; Gábor Petővári; Katalin Mészáros; Attila L. Kovács; László Patthy; Shreyas Supekar; Hao Fan; Gergely Sváb; László Tretter; Arunabh Sarkar; Aamir Nazir; Anna Sebestyén; Attila Patócs; Anil Mehta; Krisztina Takács-Vellai

15 October 2020

https://doi.org/10.1242/dmm.044925

RESEARCH ARTICLE

A lineage-tracing tool to map the fate of hypoxic tumour cells

Jenny A. F. Vermeer; Jonathan Ient; Bostjan Markelc; Jakob Kaeppler; Lydie M. O. Barbeau; Arjan J. Groot; Ruth J. Muschel; Marc A. Vooijs

30 July 2020

https://doi.org/10.1242/dmm.044768

RESEARCH ARTICLE

HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia

Joshua R. Huot; Leah J. Novinger; Fabrizio Pin; Andrea Bonetto

24 January 2020

https://doi.org/10.1242/dmm.043166