Cell biology and disease

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RESEARCH ARTICLE

Definition of the human mitochondrial TOM interactome reveals TRABD as a new interacting protein

Metin Özdemir; Silke Oeljeklaus; Alexander Schendzielorz; Marcel Morgenstern; Anusha Valpadashi; Roya Yousefi; Bettina Warscheid; Sven Dennerlein

24 April 2025

https://doi.org/10.1242/jcs.263576

TOOLS AND RESOURCES

A dual-purification system to isolate mitochondrial subpopulations

Corey N. Cunningham; Jonathan G. Van Vranken; Jakeline Larios; Katarina Heyden; Steven P. Gygi; Jared Rutter

14 April 2025

https://doi.org/10.1242/jcs.263693

SHORT REPORT

Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

Yuki Ishii; Jessica C. Orr; Marie-Belle El Mdawar; Denise R. Bairros de Pilger; David R. Pearce; Kyren A. Lazarus; Rebecca E. Graham; Marko Z. Nikolić; Robin Ketteler; Neil O. Carragher; Sam M. Janes; Robert E. Hynds

14 April 2025

https://doi.org/10.1242/jcs.263487

RESEARCH ARTICLE

Select autosomal dominant DFNA11 deafness variants activate Myo7A targeting in epithelial cells

Prashun Acharya; Garima Thapa; Xiayi Liao; Samaneh Matoo; Maura J. Graves; Sarah Y. Atallah; Ashna K. Tipirneni; Tram Nguyen; Niki M. Chhabra; Jaden Maschack; Mackenzie R. Herod; Favour A. Ohaezu; Alder Robison; Ashwini Mudaliyar; Jasvinder Bharaj; Nicole Roeser; Katherine Holmes; Vishwaas Nayak; Rayah Alsayed; Benjamin J. Perrin; Scott W. Crawley

10 April 2025

https://doi.org/10.1242/jcs.263982

RESEARCH ARTICLE

Macromolecular and cytological changes in fission yeast G0 nuclei

Zhi Yang Tan; Shujun Cai (蔡舒君); Saayli A. Paithankar; Tingsheng Liu; Xin Nie; Jian Shi; Lu Gan (甘露)

27 March 2025

https://doi.org/10.1242/jcs.263654

RESEARCH ARTICLE

An ER-associated structure sequesters misassembled FG-rich nucleoporins to help maintain nuclear pore complex function

Madison Pletan; Emily Wang; Luke Gohmann; Billy Tsai

25 March 2025

https://doi.org/10.1242/jcs.263659

REVIEW

Mitochondrial fission – changing perspectives for future progress

Sukrut C. Kamerkar; Ao Liu; Henry N. Higgs

19 March 2025

https://doi.org/10.1242/jcs.263640

SHORT REPORT

S. pombe Mis4 is required for exit from G0 as it is necessary for full nuclear separation during the subsequent M phase

Michiko Suma; Orie Arakawa; Yuria Tahara; Kenichi Sajiki; Shigeaki Saitoh; Mitsuhiro Yanagida

11 March 2025

https://doi.org/10.1242/jcs.263747

RESEARCH ARTICLE

Regulation of mitochondrial cristae organization by Myo19, Miro1 and Miro2, and metaxin 3

Samruddhi S. Shembekar; Petra Nikolaus; Ulrike Honnert; Marcus Höring; Aya Attia; Karin Topp; Birgit Lohmann; Gerhard Liebisch; Martin Bähler

06 March 2025

https://doi.org/10.1242/jcs.263637

RESEARCH ARTICLE | REVIEW COMMONS TRANSFER

Inpp5e is crucial for photoreceptor outer segment maintenance

Mohona Gupta; Tylor R. Lewis; Michael W. Stuck; William J. Spencer; Natalia V. Klementieva; Vadim Y. Arshavsky; Gregory J. Pazour

21 February 2025

https://doi.org/10.1242/jcs.263814

RESEARCH ARTICLE

Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease

Kevin Fang; Ehsan Pishva; Thomas Piers; Steffen Scholpp

05 February 2025

https://doi.org/10.1242/jcs.263526

RESEARCH ARTICLE

Mitochondrial phosphatase PPTC7 promotes EGFR recycling by facilitating VPS4A endosomal localization

Rahul Baroi; Hilal Ahmad Reshi; SubbaReddy Maddika

31 January 2025

https://doi.org/10.1242/jcs.263676

RESEARCH ARTICLE

Altered Ca 2+ responses and antioxidant properties in Friedreich's ataxia-like cerebellar astrocytes

Chiara Marullo; Laura Croci; Iris Giupponi; Claudia Rivoletti; Sofia Zuffetti; Barbara Bettegazzi; Ottavio Cremona; Paola Giunti; Alessandro Ambrosi; Filippo Casoni; Gian Giacomo Consalez; Franca Codazzi

09 January 2025

https://doi.org/10.1242/jcs.263446

RESEARCH ARTICLE

Biphasic DNA damage and non-canonical replication stress response govern radiation-induced senescence in glioblastoma

Atanu Ghorai; Bhawna Singh; Shilpee Dutt

19 December 2024

https://doi.org/10.1242/jcs.261844

RESEARCH ARTICLE

Ankyrin-B is required for the establishment and maintenance of lens cytoarchitecture, mechanics and clarity

Rupalatha Maddala; Ariana Allen; Nikolai P. Skiba; Ponugoti Vasantha Rao

18 December 2024

https://doi.org/10.1242/jcs.262349