... in the HH13 chick caudal neural plate, whose cells contribute to the neural tube, somites and notochord, node and primitive streak ( Fig. 2 E,E′). Its axial transcription then becomes confined to the region of the tailbud which includes the chick CNH and TBM (HH17; Fig. 2 F; McGrew et al., 2008 ), and has...

...Jessica B. Martin; Maria Muccioli; Kenneth Herman; Richard H. Finnell; Timothy F. Plageman, Jr ABSTRACT Folic acid supplementation can prevent neural tube defects, but the specific molecular mechanisms by which it does have not been elucidated. During neural plate morphogenesis, epithelial cell...

...Erica M. McGreevy; Deepthi Vijayraghavan; Lance A. Davidson; Jeffrey D. Hildebrand ABSTRACT Neural tube closure is a critical developmental event that relies on actomyosin contractility to facilitate specific processes such as apical constriction, tissue bending, and directional cell rearrangements...

...Debamitra Das; Jenna K. Zalewski; Swarna Mohan; Timothy F. Plageman; Andrew P. VanDemark; Jeffrey D. Hildebrand ABSTRACT Shroom3 is an actin-associated regulator of cell morphology that is required for neural tube closure, formation of the lens placode, and gut morphogenesis in mice and has been...