... apical constriction cooperates with other events to drive tissue-bending, and when defective, can result in neural tube defects. A Rho-kinase deficient binding mutant of the apical constriction regulating protein, Shroom3 (Shroom3 R1838C ), is one of only a handful of mouse mutant lines with neural tube...

... buds was severely curtailed in Cdc42 -deficient embryos. In particular, the thyroid bud epithelium did not display the apical constriction that normally occurs concurrently with the outgrowth of the bud into the underlying mesenchyme. SHROOM3, a protein that interacts with Rho GTPases and promotes...

...Vijay K. Jidigam; Raghuraman C. Srinivasan; Cedric Patthey; Lena Gunhaga ABSTRACT Epithelial invagination is a morphological process in which flat cell sheets transform into three-dimensional structures through bending of the tissue. It is accompanied by apical constriction, in which the apical...

...Erica M. McGreevy; Deepthi Vijayraghavan; Lance A. Davidson; Jeffrey D. Hildebrand ABSTRACT Neural tube closure is a critical developmental event that relies on actomyosin contractility to facilitate specific processes such as apical constriction, tissue bending, and directional cell rearrangements...

... work is properly attributed. Shroom3 Rock apical constriction epithelial neural tube The dynamic nature of the actin cytoskeleton is critical for regulating cellular processes and characteristics such as division, polarity, adhesion, migration, secretion and morphology ( Babbin et al...