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Keywords: Zika virus
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Journal Articles

Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy

Javier Gilbert-Jaramillo, Ujang Purnama, Zoltán Molnár, William S. James
Journal: Biology Open
Biol Open (2023) 12 (4): bio059889.
https://doi.org/10.1242/bio.059889
Published: 24 April 2023
... metabolism by Zika virus (ZIKV) to support its replication may contribute to damage in the developing fetal brain. Here, we showed that ZIKV replicates differently in two glycolytically distinct pools of cortical progenitors derived from human induced pluripotent stem cells (hiPSCs), which resemble...
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Includes: Supplementary data
Journal Articles

Informing epidemic (research) responses in a timely fashion by knowledge management – a Zika virus use case

Angela Bauch, Johann Pellet, Tina Schleicher, Xiao Yu, Andrea Gelemanović, Cosimo Cristella, Pieter L. Fraaij, Ozren Polasek, Charles Auffray, Dieter Maier, Marion Koopmans, Menno D. de Jong
Journal: Biology Open
Biol Open (2020) 9 (12): bio053934.
https://doi.org/10.1242/bio.053934
Published: 2 December 2020
... of existing pathophysiological knowledge. As a case study we chose the Zika virus (ZIKV) outbreak that started in 2015 to develop a proof-of-concept knowledge repository. To extract data from available sources and build a computationally tractable and comprehensive molecular interaction map we applied generic...
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Includes: Supplementary data
Journal Articles

Niclosamide rescues microcephaly in a humanized in vivo model of Zika infection using human induced neural stem cells

Dana M. Cairns, Devi Sai Sri Kavya Boorgu, Michael Levin, David L. Kaplan
Journal: Biology Open
Biol Open (2018) 7 (1): bio031807.
https://doi.org/10.1242/bio.031807
Published: 29 January 2018
...Dana M. Cairns; Devi Sai Sri Kavya Boorgu; Michael Levin; David L. Kaplan ABSTRACT Zika virus (ZIKV) is a mosquito-transmitted flavivirus with a causative link to microcephaly, a condition resulting in reduced cranial size and brain abnormalities. Despite recent progress, there is a current lack...
View articletitled, Niclosamide rescues microcephaly in a humanized in vivo model of Zika infection using human induced neural stem cells
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Includes: Supplementary data